1. Introduction & Industry Overview
Isothiazolinones are a class of broad-spectrum biocides, renowned for their superior antimicrobial performance, safety, and versatility across industrial and consumer sectors. Major product types include 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT, CAS 26172-55-4) and 2-Methyl-4-isothiazolin-3-one (MIT, CAS 2682-20-4).
With the increased focus on sustainable manufacturing, regulatory compliance (e.g., REACH, ISO 9001), and performance optimization, the global isothiazolinones market was valued at $765.4 million USD in 2023, projected to grow at a CAGR of 5.2% through 2030 (Source: MarketsandMarkets).
Key related terms: chloro isothiazolinone (CMIT), isothiazolinone price fluctuations, product grades by CAS 2682-20-4 and CAS 26172-55-4, and isothiazolinone uses in water treatment, coatings, and metallurgy.
2. Technical Parameters & Product Specifications
Both CMIT and MIT display optimal activity against bacteria, fungi, and algae, making them essential in industrial water systems, paints & coatings, papermaking, and oilfield operations. Below is a comparative specifications table of major isothiazolinones product types:
Product Type |
Chemical Name / CAS |
Appearance |
Active Content (%) |
pH (25°C) |
Solubility |
ISO/ANSI Standard |
Typical Applications |
CMIT/MIT 14% |
5-Chloro-2-methyl-4-isothiazolin-3-one / 2-Methyl-4-isothiazolin-3-one CAS 26172-55-4/2682-20-4 |
Pale Yellow Liquid |
14.0±0.5 |
2.0~4.0 |
Completely Soluble in Water |
ISO 22241, ANSI/NSF 60 |
Water Treatment, Paints, Pulp & Paper |
CMIT/MIT 1.5% |
Same as above |
Clear Liquid |
1.5±0.1 |
3.0~5.0 |
Soluble in Water |
ISO 9001:2015 |
Cosmetics, Shampoos |
CMIT 4% |
5-Chloro-2-methyl-4-isothiazolin-3-one CAS 26172-55-4 |
Light Amber Liquid |
4.0±0.2 |
2.0~5.0 |
Miscible with Water |
FDA EAFUS |
Industrial Circulating Water, Metal Processing |
MIT 10% |
2-Methyl-4-isothiazolin-3-one CAS 2682-20-4 |
Colorless Liquid |
10.0±0.4 |
6.0~9.0 |
Soluble |
ISO 14001 |
Detergents, Textile Auxiliaries |
3. Isothiazolinones Manufacturing Process Flow
Stepwise Manufacturing Schematic:
Raw Materials Selection
→
Chemical Synthesis (Chlorination/Condensation)
→
Purification & Filtration
→
Quality Inspection (ISO/ANSI/FDA)
→
Formulation & Packaging
- Raw materials: Acetone, thiourea, chlorine derivatives.
- Chemical synthesis: Controlled temperature (30-60°C), sequential chlorination and cyclization. Noteworthy for high-precision CNC blending for optimal pH and efficacy.
- Purification: Multi-step filtration (down to 0.22 microns), vacuum distillation to ensure high purity.
- Inspection standards: Adopts ISO 22241 testing, ANSI/NSF 60 potable water biocide validation, FDA protocols for residues & toxicity.
- Packing: Corrosion-resistant drums (HDPE/UN certified), batch tracking, full MSDS compliance.
Process control is enhanced with real-time PLC/SCADA monitoring and traceable batch records, offering industrial-grade consistency and reliability over a service life of 2–3 years in optimal storage.
4. Data Visualization: Technical Trends & Product Comparison
The following section presents key technical trends, market pricing, and performance metrics of isothiazolinones using interactive charts for data-driven decision support.
5. Technical Advantages: Material, Process & Quality Lead
- Raw Material Traceability: 100% feedstock trace from global certified suppliers (ISO 9001, REACH registration), ensuring product uniformity.
- Advanced Manufacturing Techniques: Processed via CNC metering blending, closed-loop additive control, and vacuum reaction, drastically reducing impurity content (
- Certification & Testing: Every batch undergoes ISO 22241 active ingredient testing; ANSI/NSF60 tested for potable water safety, and selected lots meet FDA CFR 21 for indirect food contact.
- Durability: Product stability validated under high/low temperature cycling, industry-typical shelf life ≥24 months in sealed drums.
- Environmental Compliance: VOC-free, biodegradable formulations available, lifecycle LCA evaluated for key markets.
- Anti-Corrosion, Anti-Foam: Specially engineered for minimal corrosion to system metals; foam suppression additives incorporated for closed-loop systems.
These technical strengths position Isothiazolinones (CMIT/MIT) as the preferred biocide for challenging industrial environments.
6. Manufacturer Comparison (Global Benchmarking)
Brand |
Origin |
Product Grades |
Certifications |
Annual Output (MT) |
Lead Time |
Export Market |
LKP BTC |
China |
CMIT/MIT 14%, 1.5%, MIT 10% |
ISO 22241, ANSI/NSF60, FDA |
12,000 |
7-15 days |
Global |
Dow (ROCIMA™) |
USA |
ROCMIA 607, 609 |
REACH, ISO 9001 |
9,500 |
15-25 days |
EU/US/Asia |
Lanxess |
Germany |
Preventol® CMK |
ISO 9001, ISO 14001 |
7,300 |
12-22 days |
EU/Asia |
Thor |
UK |
ACTICIDE® MBS |
ISO 9001 |
5,600 |
16-28 days |
Global |
Source: Company websites, industry reports 2023
7. Customized Solutions & Typical Applications
Isothiazolinones can be formulated to meet precise customer needs, with customization available for concentration (1.5%~14%), pH range, and specific additive technologies. Below are tailored solution scenarios:
- Petrochemical: Strong oxidizer resistance, prolonged anti-biofilm effect, certified for high-TDS brine systems.
- Metallurgy: High-temperature stable blends (up to 80°C), batch certified for process water microbiological control.
- Municipal Water: ANSI/NSF60 tested, ultra-low impurity grades for drinking water systems.
- Pulp & Paper Mills: Foam-inhibited, enhanced dispersibility to maximize wet-end process reliability.
- Paints & Coatings: Color-stability engineered; minimized impact on film formation, gloss retention tested (ASTM D523).
- Personal Care & Cosmetics: CAS 2682-20-4 pure MIT for hypoallergenic, low-sensitization preservation (compliant with EU/US limits).
Customer Feedback: LKP BTC's clients in the Middle East confirmed a 98.7% reduction in Legionella counts with CMIT/MIT versus 74% using non-isothiazolinone competitors (third-party certified, 2023). Other reported benefits include lower system corrosion, reduced biocide consumption, and improved regulatory inspection rates.
8. Application Case Studies
- Case 1: Oil Refineries, Asia – Switched from glutaraldehyde to CMIT/MIT 14% due to superior stabilization at pH 4–8, reducing annual biocide costs by 22% (Regulatory ref: GB 30962-2020).
- Case 2: Automotive Paint Shop, Europe – Adopted isothiazolinone blends eliminating 90% biofilm formation and reducing downtime, with no negative impact on gloss (validated per ASTM E2180).
- Case 3: Food Processing Plant, US – Switched to MIT (1.5%, CAS 2682-20-4) for non-rinse surface disinfection, achieving unmeasurable residuals post-cleaning (FDA LOD standard).
Our experienced tech team works closely with clients to design, trial, and validate customized chloro isothiazolinone solutions, ensuring regulatory and operational success.
9. Delivery, Quality Assurance & Customer Support
- Order Lead Time: Typical production & shipment within 7–15 days for most grades.
- Warranty: 24-month shelf-life (factory-sealed, no direct UV), with stability data available upon request.
- Certifications: ISO 9001:2015, ISO 14001:2015, ANSI/NSF60 (NSF listing), RoHS compliance available.
- QA/QC: Batch-specific COA; microbial, pH, active content, and heavy metal tests per ISO/ASTM protocols.
- Support: Dedicated technical & regulatory experts, rapid TDS/MSDS dispatch, on-site training.
- Service Regions: Americas, EU, Middle East, SEA – local warehousing by arrangement.
10. FAQ: Technical FAQ for Buyers and Engineers
Q1: What is the main difference between CMIT and MIT?
A: CMIT (5-Chloro-2-methyl-4-isothiazolin-3-one, CAS 26172-55-4) offers stronger broad-spectrum activity due to the chlorine substituent, ideal for industrial water; MIT (2-Methyl-4-isothiazolin-3-one, CAS 2682-20-4) is gentler and widely used in personal care/cosmetics.
Q2: What packaging and drum materials are used?
A: Standard packaging: 25kg/200kg HDPE drums (UN certified), with optional 1000L IBC totes and corrosion-resistant liners to ensure safe storage.
Q3: Are your products certified for drinking water use?
A: Yes, selected products are tested and certified to ANSI/NSF 60 for potable water, meeting global regulatory requirements.
Q4: Which testing standards are followed for QC?
A: We utilize ISO 22241 for active ingredient analysis, ASTM D1121 for pH, and FDA/EU protocols for trace contaminants, plus RoHS and REACH compliance as needed.
Q5: What is the recommended dosage for water treatment?
A: Typical dose: 50–150 ppm for industrial waters, depending on system contamination. Site-specific optimization supported by on-site water analysis.
Q6: How do you ensure material traceability?
A: From raw material purchase to batch packaging, each unit is traced with unique lot number, QA sheet, and COA; records maintained per ISO 9001 for 5+ years.
Q7: Do you offer technical assistance for new applications?
A: Absolutely! Our engineers provide custom formulation/compatibility advice, product selection, and regulatory document support for every client.
11. Conclusion: Trust in Isothiazolinones (CMIT/MIT) for Modern Industrial Needs
Isothiazolinones (CMIT/MIT) set the gold standard for industrial biocides—backed by robust certifications, strict quality control, and proven application cases. By leveraging advanced process technology, strict ISO/ANSI/FDA compliance, and strong customer-centric support, Isothiazolinones continue to deliver exceptional value and operational reliability in water treatment, coatings, metallurgy, and beyond. For detailed TDS, free samples, or regulatory support, contact LKP BTC.
Reference:
“Innovations in Industrial Biocides for Sustainable Water Management,” Chemical Engineering Journal Forum, Vol 391, 2024 (Link);
“Isothiazolinone Classes & Market Development,” Paints & Coatings Industry Network, 2023 (Link)