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Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent.[2] ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep tightly closed. Keep this medicine in the original container. Throw away any unused medicine after the expiration date.NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Benzalkonium chloride (BAC) is a compound commonly used as a disinfectant and preservative in various products. It is an organic salt that exhibits strong antimicrobial properties, making it effective against a wide range of bacteria, viruses, and fungi.

Benzalkonium chloride is widely used in inhalations, IM injections, nasal, ophthalmic, and topical preparations as an antimicrobial preservative, antiseptic, disinfectant, solubilizing and wetting agent. It is used in similarly to other cationic surfactants, such as cetrimide.In ophthalmic preparations, benzalkonium chloride is the preservative of choice and one of the most widely used preservatives, at concentrations of 0.01-0.02% w/v.Antimicrobial activity can be enhanced, particularly against strains of Pseudomonas, benzalkonium chloride, through combination with other preservatives or excipients, such as 0.1% w/v Disodium edetate, phenylethanol or chlorhexidine.In nasal formulations, benzalkonium chloride is used at a concentration of 0.002-0.02% w/v. Levels of 0.01% w/v have also been utilized in small-volume parenteral products.

While the misuse of antibiotics has clearly contributed to the emergence and proliferation of resistant bacterial pathogens, with major health consequences, it remains less clear if the widespread use of disinfectants, such as benzalkonium chlorides (BAC), a different class of biocides than antibiotics, has contributed to this problem. Here, we provide evidence that exposure to BAC coselects for antibiotic-resistant bacteria and describe the underlying genetic mechanisms. After inoculation with river sediment, BAC-fed bioreactors selected for several bacterial taxa, including the opportunistic pathogen Pseudomonas aeruginosa, that were more resistant to several antibiotics than their counterparts in a control (no BAC) bioreactor. A metagenomic analysis of the bioreactor microbial communities, confirmed by gene cloning experiments with the derived isolates, suggested that integrative and conjugative elements encoding a BAC efflux pump together with antibiotic resistance genes were responsible for these results. Furthermore, the exposure of the P. aeruginosa isolates to increasing concentrations of BAC selected for mutations in pmrB (polymyxin resistance) and physiological adaptations that contributed to a higher tolerance to polymyxin B and other antibiotics. The physiological adaptations included the overexpression of mexCD-oprJ multidrug efflux pump genes when BAC was added in the growth medium at subinhibitory concentrations. Collectively, our results demonstrated that disinfectants promote antibiotic resistance via several mechanisms and highlight the need to remediate (degrade) disinfectants in nontarget environments to further restrain the spread of antibiotic-resistant bacteria.

When benzalkonium chloride comes into contact with the skin, it can cause irritant contact dermatitis or allergic contact dermatitis in some individuals.Benzalkonium chloride is a well-known irritant [1]. Irritant contact dermatitis due to benzalkonium chloride is more common than allergic contact dermatitis from its use.

Benzalkonium Chloride (BZK or BAC) is a widely used antiseptic and disinfectant. It is known by several trade names, including Zephiran, Bactine, and Dettol, depending on the formulation and market. As a quaternary ammonium compound, Benzalkonium Chloride is utilized in a variety of applications, from surface disinfection to active ingredients in personal care products. The compound targets bacterial cell membranes, making it highly effective against a broad spectrum of bacteria, viruses, and fungi.

Quaternary ammonium compounds (Quats) are membrane-active agents well known for their efficacy against bacteria, fungi, algae, and enveloped viruses. A popular example is Benzalkonium Chloride (BKC), an antiseptic ingredient often formulated in topical, ophthalmic, nasal and oral preparations.By deactivating viruses through the disruption of lipid membranes, BKC is effective against a long list of enveloped viruses, including enteroviruses, rotaviruses, norovirus, influenza virus, severe acute respiratory syndrome coronavirus (SARS-CoV), rhinovirus, chlamydia, herpes simplex and hepatitis A.

Benzalkonium chloride/benzocaine is a topical solution used to treat cold sores and fever blisters. Benzalkonium chloride/benzocaine is a combination of an antiseptic and a local anesthetic that work together to prevent infection and relieve pain temporarily. Common side effects of benzalkonium chloride/benzocaine include transient stinging sensation at the application site. Check with your physician before using benzalkonium chloride/benzocaine, if you are pregnant or breastfeeding.

Benzalkonium chlorides are a quaternary ammonium compound with two alkyl groups attached to a nitrogen atom. This makes it a cationic surfactant. Cationic surfactants are compounds that attract and hold negatively charged particles, such as bacteria, onto surfaces. They are commonly used in personal care products because they help prevent bacterial growth.This QAC-based formulation is effectively active against harmful viruses, bacteria, yeast, fungi, and other cationic surfactants. It has an important role in preventing the spread of pathogens.